All functions |
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Adds ChIP-seq peak labels to the candidate sites |
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Adds ChIP-seq signals to the candidate sites |
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Assembles TOP training data for all TF x cell type combinations, then split training data into 10 partitions |
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Bins and transforms count matrix |
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Combines and takes the average of TOP posterior samples from all partitions |
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Counts DNase-seq or ATAC-seq cuts along the genome |
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Counts and normalizes (and transforms) ChIP-seq read coverage |
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Extracts regression coefficients from TOP posterior samples |
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Extracts the posterior mean of regression coefficients for each level of TOP model |
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Creates a table listing the indices and names of TF and cell type combinations from the assembled training data |
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Runs |
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Fits TOP model with M5 bins |
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Extracts count matrices around candidate binding sites |
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Gets total number of mapped reads from the |
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Indexes the FASTA file, and generates a ‘chrom.sizes’ file |
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Merges DNase or ATAC-seq counts from multiple replicates, then normalizes, bin and transform the merged counts |
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Merges DNase or ATAC-seq counts from multiple replicates, then normalizes merged counts. |
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Performs |
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Normalizes, bins and transforms counts |
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Normalizes (and transforms) ChIP-seq read coverage |
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Normalizes read counts |
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Plots DNase or ATAC profiles |
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Plots DNase or ATAC profiles by strands of motif matches |
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Predicts quantitative TF occupancy or TF binding probability |
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Obtains and filters candidate sites from FIMO result |
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Scatter plot of measured and predicted occupancy |
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Sorts, indexes the BAM file, and retrieves the |